Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans

Neuronal cell fate determinants establish the identities of neurons by controlling gene expression to regulate neuronal morphology and synaptic connectivity. However, it is not understood if have postmitotic functions in synapse pattern formation. Here we identify a novel role for UNC-4 homeobox protein its corepressor UNC-37/Groucho, tiled patterning cholinergic motor Caenorhabditis elegans . We show that unc-4 required during neurogenesis but proper patterning. In contrast, unc-37 both developing neurons. The tiling defects mutants are suppressed bar-1/β-catenin mutation, which positively regulates ceh-12/HB9 Ectopic ceh-12 partly underlies mutants. Our results reveal formation through inhibiting canonical Wnt signaling pathway.